Ever heard of a “salmon sperm facial”? That’s basically street‑speak for Rejuran—K‑Beauty’s rising star in skin regeneration. But don’t let the nickname scare you: it’s not literal fish sperm, just carefully purified salmon‑DNA polynucleotides (PN/PDRN) that scientists say are nearly 97 % compatible with human DNA
It bombed into global beauty lexicon when celebs like Jennifer Aniston and Kim Kardashian posted about their radiant “glass skin” after getting Rejuran facials The treatment is about healing your skin from the inside out—not filling it up. Let’s chew through the science, results, and real talk.
What exactly is Rejuran?
Born in South Korea, Rejuran Healer is a medical-grade skin booster using salmon‑DNA polynucleotides (PDRN). These tiny DNA fragments stimulate collagen production, boost hydration, and reset the skin’s natural repair processes — all without the bulk effect of fillers
In Asia, Rejuran is usually injected directly into the dermis. In the U.S., where injectable PDRN isn’t FDA‑approved, it’s combined with microneedling or RF devices to push it into the deeper layers
How it works — in plain English
Here’s the gist: the purified salmon DNA binds to your skin’s A2A receptors. This calms inflammation, speeds up cell repair, and gently wakes up your fibroblasts—the cells that produce collagen and hyaluronic acid
Basically, it’s like handing your skin a “repair kit.” Within a week, users notice smoother texture; by four weeks, skin looks firmer, more hydrated, and visibly renewed .
Key benefits
Healing & hydration: Polys soak up moisture and foster rapid cell turnover for softer, yummier-feeling skin .
Fine‑line and pore reduction: Collagen surge means fewer mini-lines, tighter pores, and smoother tone .
Scar and pigmentation improvement: Ideal for mild acne scarring and sunspots, as cell renewal fades imperfections
Inflammation support: Perfect for sensitive or reactive skin—helps calm redness after treatments
What the process feels like
The session: 30–60 minutes after numbing cream, mixed with tiny injections or microneedling/RF to introduce PDRN
Recommended course: 3–4 sessions spaced 3–4 weeks apart, plus a maintenance boost every 6–12 months .
Downtime: Minimal—some redness, mild swelling or pinpoint bruises clear up in 24–72 hours .
Aftercare: Ditch heavy creams, sun, and exfoliants (AHAs/retinol) for about 48 hours. Loose skincare, SPF, and gentle hydration are your friends .
Side effects & safety
Expect mild redness, swelling, or bruising that fades within a few days—that’s normal .
On rare occasions, tiny bumps or tenderness may occur, but they usually go away on their own .
Allergic reactions or infections are extremely rare—always choose a certified clinic with solid hygiene standards. In the U.S., since injections aren’t approved, these are microneedling-assisted treatments only
Rejuran vs PRP — quick side‑by‑side
| Feature | Rejuran (PDRN) | PRP (Platelet‑Rich Plasma) |
|---|---|---|
| Source | Purified salmon DNA (standardised) | Your own blood (variable quality) |
| Mechanism | Repairs at DNA level, receptor-driven | Growth factors from platelets |
| Allergy risk | Low (antigens removed) | None |
| Prep | Off-the-shelf, ready to use | Requires blood draw and prep |
| Consistency | Same formula every time | Patient’s blood health-dependent |
| Animal origin | ❌ Yes | ✅ No |
In summary: Rejuran delivers a precision‑engineered regenerative boost, while PRP is zero‑risk (allergy‑wise) and blood‑derived—so your choice depends on whether you prefer standardised results or an animal-free option
Real results — before and after
Clinical trials show measurable improvements in skin thickness, hydration, elasticity, and pore size after the recommended course
One woman who tried the treatment in NYC noted:
“Redness subsided in hours…I skipped makeup for a weekend and woke up glowing.”
Celebrities rave about achieving that coveted “glass skin” glow—smooth, dew‑luminous and radiant within just days . But remember: effects build cumulatively over weeks—not overnight magic.
FAQ’s by real people
Does it hurt?
With numbing cream, most report mild stinging or pressure—manageable and far from painful .
I’m allergic to seafood—is that an issue?
Salmon DNA is highly purified, and proteins removed—but always disclose allergies and do a patch test first.
How long do results last?
Glow peaks by 4 weeks, and lasts approximately
6–12 months. Maintenance sessions keep benefits rolling .
Can it help under‑eyes or acne scars?
Yes—many clinics use Rejuran S or specific formulations to soften under‑eye lines, scars, and pore texture issues through collagen remodelling .
Advanced twists & lesser‑known angles
Rejuran variants:
HB (Hydration Hero): Extra-moisture focus, plumps dry skin.
S (Scar Solution): Concentrated formula for textured, scarred skin.
Needleless or at-home fixes: Brands are testing topical PN creams and masks—but results are delayed compared to in‑clinic delivery.
Not just faces: Clinics in Australia and Thailand are experimenting with Rejuran for hair thinning and stretch marks—ongoing studies, but data is limited .
What to ask your clinic
Which Rejuran variant are you using (Healer, HB, S)?
Do you inject directly or use microneedling/RF?
Can you show before‑after from your patients?
What safety measures and post‑care protocols do you follow?
Expected price range: $600–2 000 per session, depending on location and device use.
Final word
Rejuran isn’t hype—it’s a roots‑down, science‑backed treatment that genuinely regenerates. It isn’t cheap, won’t work overnight, and it involves multiple sessions. But if you’re after smarter skin rejuvenation—not fillers or empty promises—Rejuran deserves serious attention.
Ready to glow? Book a consultation with a certified clinic. Ask your practitioner which formulation fits your skin profile, and plan your series for the results you deserve.